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Selected Publications

Representative publications on MRI of Gene Transcription

  1. Liu CH, Ren JQ, Yang J, Liu CM, Mandeville JB, Rosen BR, Bhide PG, Yanagaza Y, Liu PK, "DNA-based MRI Probes for Specific Detection of Chronic Exposure to Amphetamine in Living Brains," Journal of Neuroscience, 2009, 29(34): 10663-10670.
  2. Liu CH, You Z, Ren JQ, Kin YR, Whalen MJ, Rosen BR, Liu PK, "Diffusion-Weighted MRI Reversal by Gene Knockdown of Matrix Megalloproteinase-9 Acitivies in Live Animal Brains," Jornal of Neuroscience, 2009, March:29(11)3508-3517.
  3. Liu, CH, You Z, Ren J, Kim YR, Eikermann-Haerter K, Liu PK (2008) Noninvasive delivery of gene targeting probes to live brains for transcription MRI. FASEB J 22:1193-203
  4. Liu CH, Kim YR, Ren JQ, Eichler F, Rosen BR, Liu PK. (2007) Imaging cerebral gene transcripts in live animals. J Neurosci. 27(3):713-22.
  5. Liu CH, Huang S, Kim YR, Rosen BR, Liu PK (2007). Forebrain ischemia-reperfusion simulating cardiac arrest in mice induces edema and DNA fragmentation in the brain. Mol Imaging. 6(3):156­-170
  6. Liu CH, Huang S, Cui J, Kim YR, Farrar CT, Moskowitz MA, Rosen BR, Liu PK (2007) MR contrast probes that trace gene transcripts for cerebral ischemia in live animals. FASEB J 21:3004-3015.

 

Other Research Interests:

Imaging DNA Repair of the Central Nervous System:

  1. Mendez, D, Cherian L, Moore N, Arora T, Liu PK, Robertson CS. (2004) Oxidative DNA Lesions in a Rodent Model of Traumatic Brain Injury. J. Trauma, 56(6):1235-40
  2. Moore N, Okocha F, Cui JK, Liu PK. (2002) Homogeneous repair of nuclear genes after experimental stroke. J Neurochem. 80(1):111-8.
  3. Cui J, Liu PK. (2001) Neuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injury. J Biomed Sci. 8(4):336-41.
  4. Huang D, Shenoy A, Cui J, Huang W, Liu PK. (2000) In situ detection of AP sites and DNA strand breaks bearing 3'-phosphate termini in ischemic mouse brain. FASEB J. 14(2):407-17.
  5. Cui J, Holmes EH, Greene TG, Liu PK. (2000) Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. FASEB J. 14(7):955-67.
  6. Lin LH, Cao S, Yu L, Cui J, Hamilton WJ, Liu PK. (2000) Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion. J Neurochem. 74(3):1098-105.
  7. Cui J, Holmes EH, Liu PK. (1999) Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia. J Neurochem. 73(3):1164-74.
  8. Gu ZZ, Pan YC, Cui JK, Klebuc MJ, Shenaq S, Liu PK. (1997) Gene expression and apoptosis in the spinal cord neurons after sciatic nerve injury. Neurochem Int. 30(4-5):417-26.
  9. Liu PK, Hsu GS. (1990)  On the DNA polymerase-a mutant: immunofluorescence assay of UV-induced thymidine dimers in Aphr-4-2 cells. Somat Cell Mol Genet. 16(1):49-57.
  10. Liu PK, Goudreau B, Hsu GS. (1989) Aphidicolin hypersensitive mutant of Chinese hamster V79 fibroblasts that underproduces DNA polymerase-alpha antigen. Somat Cell Mol Genet. 15 (4):331-44.

Genetic Therapy

  1. Cui JK, Hsu CY, Liu PK. (1999) Suppression of postischemic hippocampal nerve growth factor expression by a c-fos antisense oligodeoxynucleotide. J Neurosci. 19(4):1335-44.
  2. Liu PK, Kraus E, Wu TA, Strong LC, Tainsky MA. (1996) Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations. Oncogene.12(11):2267-78.
  3. Liu PK, Salminen A, He YY, Jiang MH, Xue JJ, Liu JS, Hsu CY. (1994) Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA. Ann Neurol. 36(4):566-76.
  4. Liu PK, Loeb LA. (1984) Transfection of the DNA polymerase-alpha gene. Science.226 (4676):833-5.

Molecular Basis of Mutation

  1. Liu PK, Hsu CY, Dizdaroglu M, Floyd RA, Kow YW, Karakaya A, Rabow LE, Cui JK. (1996) Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion. J Neurosci. 16(21):6795-806.
  2. Liu PK, Chang CC, Trosko JE, Dube DK, Martin GM, Loeb LA. (1983) Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha. Proc Natl Acad Sci U S A. 80(3):797-801.