Jorge Sepulcre is
a faculty member at the Division of Nuclear Medicine and
Molecular Imaging, Massachusetts General Hospital, Harvard
Medical School.
His research focuses on brain imaging studies aiming at the
understanding
of large-scale brain networks implicated in human cognition
and
neurodegenerative disorders such as Alzheimer's disease. He
uses
functional connectivity MRI and network theory techniques
to untangle
network properties of the human brain. Recently, he has
described that
cerebral cortex is organized in regions of preferential
local and distant
functional connectivity. This cortical organization
presumably drives
essential principles of brain information processing such
as
specialization and integration.
Sepulcre,
J., Liu, H.,
Talukdar, T., Martincorena, I., Yeo, B.T.T., Buckner, R.L.
(2010) The Organization of Local and Distant Functional
Connectivity in the Human Brain. PLoS Comput Biol;
6(6):e1000808. [medline abstract]
Andews-Hanna, J., Reidler, J.S., Sepulcre, J., Poulin, R., Buckner, R.L. (2010)
Functional-anatomic fractionation of the brain's default
network. Neuron; 65(4):550-62. [medline abstract]
Sepulcre,
J., Masdeu, J.,
Pastor, M.A., Goñi, J.,
Barbosa, C., Bejarano, B., Villoslada, P. (2009) Brain
pathways of verbal working memory: A lesion-function
correlation study. Neuroimage; 47(2):773-8.
[medline abstract]
Buckner, R.L., Sepulcre, J., Talukdar, T., Krienen, F., Liu, H.,
Hedden, T., Andrews-Hanna, J., Sperling, R.A., Johnson,
K.A. (2009) Cortical hubs revealed by intrinsic functional
connectivity: mapping, assessment of stability, and
relation to Alzheimer's disease. J Neurosci;
29(6):1860-73. [medline abstract]
