May 11, 2020 The presubiculum links incipient amyloid and tau pathology to memory function in older persons Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Neurology. 2020 May 5;94(18):e1916-e1928. doi: 10.1212/WNL.00...
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Chongzhao Ran
Chongzhao Ran, PhD, is an Associate Professor in Radiology at Massachusetts General Hospital and Harvard Medical School. He received a Master's degree in medicinal chemistry from China Pharmaceutical University and a PhD in medicinal chemistry from Shanghai Institute of Pharmaceutical Industry, C...
Hamid Sabet
Hamid Sabet, is Assistant Professor of Radiology at Harvard Medical School and a Cyclotron/Medical Physicist at the Division of Nuclear Medicine and Molecular Imaging, Radiology Department, Massachusetts General Hospital. He is the director of Radiation Physics and Instrumentation Lab at the Mart...
Smart Chemiluminescence Probe Facilitates Optical Imaging of Amyloid-Beta
Developed by Chongzhao Ran and colleagues, the probe greatly improves the ability to detect amyloid-beta in vitro and in a mouse model of Alzheimer's disease.
Moving Beyond Biopsy for Liver Fibrosis
Chronic liver disease is a growing health concern in the U.S. and around the world, with links to alcoholism, diabetes and even obesity. One of the early manifestations of the disease is fibrosis, an excessive buildup of scar tissue that results from repeated injury to the liver. While its effect...
The Martinos Center and the Institute for Innovation in Imaging Support Clinical Trial of Drug for Patients with Idiopathic Pulmonary Fibrosis
Researchers from the Division of Pulmonary and Critical Care Medicine, the Martinos Center, and the Institute for Innovation in Imaging (i3) at Massachusetts General Hospital recently completed a 12-week, randomized, double-blind, placebo-controlled trial of bexotegrast (PLN-74809), a drug develo...
Yi-Fen Yen
Over the past two decades, Dr. Yen has devoted herself to the development of advanced MRI techniques, for hyperpolarized metabolic imaging, cancer imaging and functional imaging in clinical and pre-clinical research. She is an MR physicist with >100 publications in peer-reviewed scientific jou...
Acupuncture Yields Improved Outcomes in Carpal Tunnel Syndrome
Though the practice of acupuncture predates current understanding of physiology by several millennia, it often provides measureable improvements in health outcomes, particularly in the area of chronic pain. Now, in a study reported in the journal Brain, a team of investigators based at the Athino...
Visualizing the Mind: How We See the Brain Through Functional MRI
Last year, Harvard College senior Kelsey Ichikawa (shown in the photo above) interviewed the Martinos Center’s Bruce Rosen and Bruce Fischl for a general audience article about functional MRI, which she was writing for a science journalism course. Earlier this year, the article won the Harvard Bo...
The Neuroscience of Personal Space
We all have a need for personal space, the comfort zone we maintain around our bodies, implicitly entreating others not to encroach upon it. In recent years researchers have been probing the ways in which we regulate this space, looking at how and why our brains tell us when someone is simply ...
Estimating Tumor Boundaries in Cancer Surgery With Fluorescence Lifetime Imaging
Cancer is the second leading cause of death in the United States, with an estimated 1,762,450 new cases diagnosed and 606,880 deaths in 2019 alone. While important advances have been made in the development of treatments for cancer, including surgery, a number of challenges remain. Not least: sur...
New Software Improves Ability to Determine the Cause of Stroke
Determining the cause of an ischemic stroke is critical to preventing a second one and is a primary focus in the evaluation of stroke patients. But for all the importance of identifying the cause, physicians have long lacked a robust and objective means to do so. Now a team of investigators at...
Xue-Jun (June) Kong
Xue-Jun (June) Kong, M.D. Principal Investigator and Director of Synapse Autism program at Martinos Center/Mass General Hospital, Principal Investigator and Attending Physician at Beth Israel Deaconess Medical Center, Assistant Professor of Harvard Medical School. She leads her Autism research te...
Kestas Kveraga
Dr. Kveraga is a cognitive neuroscientist who studies the neural mechanisms of threat perception from naturalistic stimuli, with strong interests in visual pathway function and autism. He is also interested in neural aesthetics and how brain activity can be employed to predict and shape architect...
Xin Yu
Xin Yu studied Neuroscience and Biophysics at New York University, USA. During his Ph.D. training in Dan Turnbull’s lab, he implemented Manganese-enhanced MRI to study the auditory midbrain plasticity and mid-hindbrain development. Meanwhile, he was trained by Dan Sanes to target the inferior col...
Study Confirms Role of Structural Connectivity in Spread of Alzheimer’s Disease Pathology
In Alzheimer’s, the proteins amyloid-beta and tau begin to accumulate in the brain many years before any clinical signs of the disease are evident. Propagation of these proteins throughout the brain has been linked to cognitive decline in Alzheimer’s, but exactly how they spread has long been a m...
How iPads and Other Tablet Devices Could Improve Communication Skills in People With Autism
In recent years researchers have gained an increased understanding of the relationship between motor skills and the development of language, particularly in autism spectrum disorder (ASD). Given the core deficit in verbal communication in children and adults on the spectrum, the improved understa...
Early Screening of ASD With a New Eye-tracking Paradigm
Studies have shown that early diagnosis and intervention significantly impact the prognosis of individuals with autism spectrum disorder (ASD): the earlier the detection and diagnosis, the better the prognosis and functional status later in life. Currently, the average age of diagnosis is approxi...
Uncovering ‘Covert Consciousness’ in Brain Injury Patients
In a paper published in the journal Brain last month Brian Edlow and colleagues reported a study in which they used the imaging techniques functional MRI and EEG to detect ‘covert consciousness’ in the intensive care unit. We checked in with Edlow, associate director of the Center for Neurotechno...
Sava Sakadzic
Dr. Sakadzic obtained his Ph.D. with Dr. Lihong Wang at Texas A&M University and completed his postdoctoral training with Dr. David Boas at the Massachusetts General Hospital. His group is developing state-of-the-art optical microscopy imaging technologies and utilizing them to better understand ...