What if you held a clinical trial and nobody came? While plenty of patients are eager to participate, researchers often have difficulty reaching their target enrollments for clinical trials, the goal of which is to determine the safety and efficacy of new drugs or therapies before they are bro...
Search Results: Clinical
The Clinical Potential of Molecular Imaging of Pulmonary Fibrosis
Peter Caravan and Sydney Montesi discuss the potential of molecular imaging of pulmonary fibrosis for managing patients with interstitial lung disease and other clinical applications.
Artificial Intelligence Improves Treatment Monitoring in Patients with Glioma
This year, some 78,000 primary brain and other central nervous system (CNS) cancers will be diagnosed in the US alone. Researchers are actively developing new therapies for glioma, the most common type of primary brain tumor, but challenges remain in assessing whether patients are responding to t...
Eva-Maria Ratai
Dr. Eva-Maria Ratai has been Director of Clinical Magnetic Resonance Spectroscopy at Massachusetts General Hospital (MGH) since 2003. After completing her doctoral thesis in physical chemistry at the University of Münster in Germany in 2000, and her first post-doctoral position in the Department ...
Magnetoencephalography Aids Diagnosis and Treatment of Epilepsy, Other Disorders
Originally used only for research purposes, magnetoencephalography (MEG) has been introduced into clinical care in recent decades. With applications in epilepsy already benefiting from its use, and still others on the horizon, the technique is helping to advance diagnosis and treatment for a rang...
Randy Gollub
Randy Gollub, MD, PhD, is Professor of Psychiatry at Harvard Medical School and Clinical Professor of Psychiatry with a secondary appointment in Radiology at Massachusetts General Hospital, where she serves as the Associate Director of Translational Research in the Neuroimaging Research Program. ...
Hakan Ay
Dr. Hakan Ay is an MD with residency training in Neurology and fellowship training in Vascular Neurology. He currently serves as an Associate Professor at Harvard Medical School with appointments in both departments of Neurology and Radiology at the Massachusetts General Hospital. Dr. Ay has 28 y...
Estimating Tumor Boundaries in Cancer Surgery With Fluorescence Lifetime Imaging
Cancer is the second leading cause of death in the United States, with an estimated 1,762,450 new cases diagnosed and 606,880 deaths in 2019 alone. While important advances have been made in the development of treatments for cancer, including surgery, a number of challenges remain. Not least: sur...
White Matter Changes Could Predict Cognitive Decline in Alzheimer’s Disease
Alzheimer’s disease is diagnosed based on abnormal pathology of two proteins in the brain: amyloid and tau. Research suggests, however, that other factors may also play a role. In a paper published online this week in the journal Neurology, a team of investigators at the Athinoula A. Martinos Cen...
Learning to See: New Artificial Intelligence Technique Dramatically Improves the Quality of Medical Imaging
A radiologist’s ability to make accurate diagnoses from high-quality diagnostic imaging studies directly impacts patient outcome. However, acquiring sufficient data to generate the best quality imaging comes at a cost – increased radiation dose for computed tomography (CT) and positron emission t...
Christopher Nguyen
The Nguyen lab focuses on the development and clinical application of novel imaging techniques to characterize the cardiovascular system including MRI, optical, and PET. Our primary research interests fall into four general areas: (1) bio- inspired design for heart assisted devices (Science Robot...
Yi-Fen Yen
Over the past two decades, Dr. Yen has devoted herself to the development of advanced MRI techniques, for hyperpolarized metabolic imaging, cancer imaging and functional imaging in clinical and pre-clinical research. She is an MR physicist with >100 publications in peer-reviewed scientific jou...
New Software Improves Ability to Determine the Cause of Stroke
Determining the cause of an ischemic stroke is critical to preventing a second one and is a primary focus in the evaluation of stroke patients. But for all the importance of identifying the cause, physicians have long lacked a robust and objective means to do so. Now a team of investigators at...
Ona Wu
The research goals of Dr. Wu's group are to improve the diagnosis, prognosis and management of patients with brain injury by quantifying and monitoring injury or recovery on an individual patient basis. The group focuses particularly on stroke, cardiac arrest and traumatic brain injury. Predictin...
Novel PET Radiotracer Offers Possible ‘Smell Test’ for Dementia
Olfactory health – how well we are able to smell – is a reliable marker of the health of the brain, but the “smell identification tests” commonly used in studies of olfactory health do not offer a complete picture of what is happening. Now, using a novel PET radiotracer called Neuroflux, a team o...
Magnetic Resonance Imaging
The Center's magnetic resonance imaging (MRI) facilities include the following. Large-bore MRI Systems * All subject bays are equipped with Blu-ray/DVD players for subject entertainment Bay 1: Siemens 3T MRI Skyra with 128ch receive capabilities and 2ch pTx This is a Siemens 3T Skyra wit...
Steven Stufflebeam
Steven Stufflebeam, MD, translates basic science and advanced imaging technology into everyday clinical practice. His laboratory aims to improve the health care for patients with epilepsy, schizophrenia, brain tumors and hearing impairments. His training is in biomedical engineering, mathematics ...
Stephen Cauley
Stephen Cauley, PhD, is an Assistant Professor of Radiology at Harvard Medical School. He received his BS and PhD in Electrical & Computer Engineering (ECE) from Purdue University. Prior to joining the A.A. Martinos Center for Biomedical Imaging he held positions as a Visiting Assistant Profe...
Bin Deng
Bin Deng, PhD, is a biomedical scientist whose research interests revolve around near-infrared (NIR) spectroscopy, functional optical imaging, the interactions between NIR light and tissue, noninvasive optical biomarkers and the pathophysiology of diseases. Dr. Deng investigates the intersection ...
Maria Angela Franceschini
Maria Angela Franceschini, PhD, is widely recognized as a leader in the field of diffuse optical imaging in both neuroscience and clinical neuro-monitoring applications. Her research interests lie mainly in the development of novel optical imaging methods to achieve a deeper understanding of the ...