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DTSTART;TZID=America/New_York:20200805T120000
DTEND;TZID=America/New_York:20200805T130000
DTSTAMP:20260424T094513
CREATED:20200803T192933Z
LAST-MODIFIED:20200803T192933Z
UID:9629-1596628800-1596632400@www.martinos.org
SUMMARY:BrainMap: Cortical-Like Dynamics in Recurrent Circuits Optimized for Sampling-Based Probabilistic Inference
DESCRIPTION:Rodrigo Echeveste\, Ph.D\,  Argentina’s National Research Council (CONICET) \nAbstract: \nThe dynamics of sensory cortices show a suite of basic\, ubiquitous features that have so far escaped a common\, principled theoretical account. These include strong inhibition-dominated transients at stimulus onset\, gamma oscillations\, and noise variability – all stimulus-dependent. We present a unifying model in which all these dynamical phenomena emerge as a consequence of the efficient implementation of the same computational function: fast probabilistic inference. For this\, we use a novel approach and train a recurrent E/I neural circuit model of a V1 hypercolumn. The network is required to modulate not only the mean (as conventional) but also the variability of its stationary response distributions in order to match the corresponding input-dependent posterior distributions inferred by an ideal observer. The optimized neural circuit features a number of remarkable properties. Firstly\, the network discovers non-equilibrium dynamics\, a state-of-the-art machine learning strategy to speed up inferences. The circuit also exhibits realistic biological properties for which it was not trained directly. It achieves divisive normalization and displays marked transients at stimulus onset\, as well as strong gamma oscillations\, both scaling with stimulus contrast. Crucially\, these dynamical phenomena do not emerge in other control networks trained to match either mean responses only\, or mean responses and variances (without modulating response co-variances). This model allowed us to make predictions regarding the tuning of transient responses that we later confirmed in novel analyses of awake monkey V1 recordings. \nBrief bio: \nRodrigo Echeveste obtained his Bachelor and Masters Degrees in Physics from Balseiro Institute in Argentina\, and his PhD from the Goethe University in Frankfurt\, Germany. After a three year stay in the UK as a postdoc at Cambridge University’s Computational and Biological Learning Lab (CBL)\, he returned to Argentina where he now holds a permanent research position from Argentina’s National Research Council (CONICET) at the Research Institute for Signals\, Systems and Computational Intelligence\, sinc (i). \nZoom Link: https://zoom.us/j/153319823 \nOr iPhone one-tap :\nUS: +13126266799\,\,153319823# or +16468769923\,\,153319823#\nOr Telephone:\nDial(for higher quality\, dial a number based on your current location):\nUS: +1 312 626 6799 or +1 646 876 9923 or +1 301 715 8592 or +1 346 248 7799 or +1 408 638 0968 or +1 669 900 6833 or +1 253 215 8782\nWebinar ID: 153 319 823\nInternational numbers available: https://zoom.us/u/adBWphwtx6 \n  \n\n  \nSpeaker \nRodrigo Echeveste\, Ph.D\,  Argentina’s National Research Council (CONICET)
URL:https://www.martinos.org/event/brainmap-200803/
CATEGORIES:BrainMap
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DTSTART;TZID=America/New_York:20200819T120000
DTEND;TZID=America/New_York:20200819T130000
DTSTAMP:20260424T094513
CREATED:20200814T191350Z
LAST-MODIFIED:20200814T191350Z
UID:9641-1597838400-1597842000@www.martinos.org
SUMMARY:BrainMap: Sprouting and Regeneration of Peripheral Axons in Nerve injury and Disease Models
DESCRIPTION:Mohamed Farah\, Associate Professor of Neurology and Neuroscience\, Johns Hopkins University School of Medicine \n\nZoom Link: https://zoom.us/j/153319823 \nOr iPhone one-tap :\nUS: +13126266799\,\,153319823# or +16468769923\,\,153319823#\nOr Telephone:\nDial(for higher quality\, dial a number based on your current location):\nUS: +1 312 626 6799 or +1 646 876 9923 or +1 301 715 8592 or +1 346 248 7799 or +1 408 638 0968 or +1 669 900 6833 or +1 253 215 8782\nWebinar ID: 153 319 823\nInternational numbers available: https://zoom.us/u/adBWphwtx6 \n  \n\n  \nSpeaker \nMohamed Farah\, Associate Professor of Neurology and Neuroscience\, Johns Hopkins University School of Medicine
URL:https://www.martinos.org/event/brainmap-200819/
CATEGORIES:BrainMap
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200826T120000
DTEND;TZID=America/New_York:20200826T130000
DTSTAMP:20260424T094513
CREATED:20200825T131537Z
LAST-MODIFIED:20200825T131537Z
UID:9659-1598443200-1598446800@www.martinos.org
SUMMARY:BrainMap: Awake\, Behaving Functional Imaging of the Marmoset at 9.4 T
DESCRIPTION:Dr. Ravi Menon\, Professor of Medical Biophysics\, Medical Imaging\, Physics and Psychiatry at Western University\, Canada \nAbstract: \nMarmosets are small New World primates that could become an important preclinical animal model for studying human brain diseases. A critical step in the development of marmosets as a viable model for human brain dysfunction is to characterize brain networks that are homologous with human network topologies. It’s also important to understand if these network topologies are shared with rodents\, the model in which the vast majority of preclinical work has been performed to date. I will review our MRI developments that have allowed us to develop awake\, behaving marmoset imaging at 9.4T.  I’ll then discuss some results from awake fMRI studies of these animals including recent work where we compare whole-brain functional connectivity fingerprinting of the medial frontal cortex (MFC) in rodents\, marmosets and humans. We observe a remarkably similar intrinsic functional organization of the MFC across the three species\, but clear differences between rodent and primate MFC whole-brain connectivity. In contrast to the common proposal that the rat MFC is functionally analogous with the primate lateral (LFC)\, our results demonstrate clear differences between the rodent MFC and primate LFC interareal functional connectivity. This cautions the use of rodents for behaviours and disorders involving the dorsolateral prefrontal cortex in humans. \nBio: \nDr. Ravi Menon is a Professor of Medical Biophysics\, Medical Imaging\, Physics and Psychiatry at Western University\, where he is also a member of the Graduate Program in Neuroscience and the Graduate Program in Biomedical Engineering and Founding Director of Western’s Centre for Functional and Metabolic Mapping (CFMM)\, Canada’s only ultra-high field MRI facility. He holds a Ph.D. in Medicine from the University of Alberta (1990)\, a M.Sc.(A) in Medical Physics from McGill University and a B.Sc. (Hons) in Physics from the University of British Columbia. He did his postdoctoral work in the laboratory of Dr. Kamil Ugurbil at the University of Minnesota. He was awarded one of the inaugural Canada Research Chairs in 2001.  He has held grants from a broad spectrum of national and international funding agencies including a CIHR Foundation Grant in 2016. He currently serves as co-Scientific Director of BrainsCAN\, a $66M grant from the Canada First Research Excellence Fund. \nHe is twice an awardee of Canada’s Top 40 under 40 program and one of 20 recipients of the Young Explorers Medal from the Canadian Institute for Advanced Research. In 2015\, he was elected as a Senior Fellow of the International Society for Magnetic Resonance in Medicine and the Canadian Academy of Health Sciences. In 2019 he was inducted as a Fellow of the Royal Society of Canada. \nHe has served in numerous advisory capacities\, including 7 years on the Canada Gairdner Foundation and the Board of Scientific Councilors of NIMH/NIH. He served for 7 years (the last 4 as Chair) on the Institute Advisory Board of the Institute for Neuroscience\, Mental Health and Addiction of the CIHR. He currently serves on the Board of the Brain Canada Foundation along with several of Canada’s leading Philanthropists. \nZoom Link: https://zoom.us/j/153319823 \nOr iPhone one-tap :\nUS: +13126266799\,\,153319823# or +16468769923\,\,153319823#\nOr Telephone:\nDial(for higher quality\, dial a number based on your current location):\nUS: +1 312 626 6799 or +1 646 876 9923 or +1 301 715 8592 or +1 346 248 7799 or +1 408 638 0968 or +1 669 900 6833 or +1 253 215 8782\nWebinar ID: 153 319 823\nInternational numbers available: https://zoom.us/u/adBWphwtx6 \n  \n\n  \nSpeaker \nDr. Ravi Menon\, Professor of Medical Biophysics\, Medical Imaging\, Physics and Psychiatry at Western University\, Canada
URL:https://www.martinos.org/event/brainmap-200826/
CATEGORIES:BrainMap
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