BrainMap: X-Nuclei MR Spectroscopy of the Heart: Insights from 23Na, 31P, and 13C NMR
2025-10-08 12:00 - 13:00 (America/New_York)
Speaker: Ivan Luptak, MD, PhD, is an Associate Professor of Medicine at Boston University School of Medicine and a cardiologist at Boston Medical Center.
Bio: Ivan Luptak, MD, PhD, is an Associate Professor of Medicine at Boston University School of Medicine and a cardiologist at Boston Medical Center. His research focuses on cardiac energy metabolism, mitochondrial biology, and translational imaging approaches to hypertrophic cardiomyopathy and metabolic heart disease. His laboratory employs multi-nuclear MR spectroscopy (23Na, 31P, and 13C) in ex vivo Langendorff-perfused hearts, in vivo 31P NMR, and multi-omics analyses to define energetic dysfunction and test novel therapeutic interventions. He is PI of an NIH R01 on targeting energetics in HCM and maintains active collaborations with academic and industry partners, including recent work with the Martinos Center in hyperpolarized 13C imaging.
Abstract: Energetics and ion homeostasis are central to cardiac performance, but their direct measurement in intact tissue remains challenging. My laboratory uses multi-nuclear magnetic resonance spectroscopy — including 23Na, 31P, and non-hyperpolarized 13C — in isolated Langendorff-perfused hearts to probe energetic metabolism and substrate fluxes under stress and disease conditions. Over the past two decades, we have applied these approaches to define how mitochondrial dysfunction, impaired ATP production, and abnormal sodium handling contribute to diastolic dysfunction and impaired contractile reserve in models of hypertrophic cardiomyopathy (HCM) and metabolic heart disease. These tools have allowed us to dissect mechanisms such as oxidative inhibition of respiratory chain proteins, altered sarcomeric power efficiency, and the interplay between sodium
loading and mitochondrial energetics.

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BrainMap: Total-Body PET Across Scales and Systems
2025-10-09 11:00 - 12:00
Speaker: Kevin J. Chung, PhD, American Heart Association (AHA) Postdoctoral Fellow in the Department of Radiology at UC Davis Health

Bio: Kevin J. Chung, PhD, is an American Heart Association (AHA) Postdoctoral Fellow in the Department of Radiology at UC Davis Health, supervised by Drs. Guobao Wang and Simon Cherry. He obtained his PhD in Medical Biophysics from Western University
(London, Canada) in 2023 under the supervision of Dr. Ting-Yim Lee, where he optimized brain CT perfusion imaging for acute ischemic stroke. At UC Davis, he has developed novel total-body PET kinetic modeling approaches for quantitative imaging of blood flow across the body with 18F-FDG and blood-brain barrier permeability at the molecular level. His AHA fellowship focuses on developing total-body multiparametric PET tools for investigating the brain-heart axis, and more broadly, he is interested in developing methods to elucidate how the brain and body are functionally interconnected. Kevin’s work has been recognized with several early career awards, including the ISCBFM Niels Lassen Award at the 2025 Brain and Brain PET Conference.
Abstract: The recent advent of total-body PET is enabling new imaging opportunities with its order-of-magnitude increase in signal sensitivity and unique ability to dynamically image the entire body at once. Our work is pushing the boundaries of high-temporal resolution dynamic imaging to enable total-body multiparametric PET, overcoming limitations of conventional single-parametric PET imaging. Here we describe how we are exploiting the high performance of this new technology for quantitative imaging across scales and systems – from measuring blood flow across the entire body to blood-brain barrier permeability at the molecular level. We then show the potential of total-body PET for opportunistic studies of inter-organ connections, such as blood-brain barrier dysregulation in systemic liver disease. Our work builds toward a powerful human imaging platform for more comprehensively characterizing health and disease from a systems perspective.
This is a Special BrainMap seminar.

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BrainMap: Brain Microstructure Imaging with Diffusion MRI
2025-10-15 12:00 - 13:00
Speaker: Dr. Santiago Coelho, NYU School of Medicine
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BrainMap: Psychedelic rewiring of neuroimmune circuits in psychiatric disorders
2025-11-05 12:00 - 13:00
Speaker: Dr. Michael Wheeler
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BrainMap: Neuronal Activity-Related Sodium (NARS) fMRI Method
2025-11-12 12:00 - 13:00
Speaker: Dr. Xin Yu
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BrainMap: Magnetic Particle Imaging (MPI) for functional brain imaging; rodent and human-scale devices
2025-11-19 12:00 - 13:00
Speaker: Lawrence L. Wald Ph.D., A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Harvard Medical School, Harvard-MIT Division of Health Science Technology
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BrainMap: Neural Correlates of Cognitive Abilities in the Human Connectome Project-Aging/Aging Adult Brain Connectome Cohort
2025-12-03 12:00 - 13:00
Speaker: Prof. David Salat — MGH Martinos Center / Harvard Medical School
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BrainMap: Acoustic holograms for personalized ultrasonic neuromodulation and drug delivery into the brain
2025-12-10 12:00 - 13:00
Speaker: Prof. Antonios Pouliopoulos — King’s College London
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BrainMap: Update on the Center for Mesoscale Mapping (P41)
2025-12-17 12:00 - 13:00
Speaker: Prof. Bruce Rosen (et al.) — Director of the Athinoula A. Martinos Center for Biomedical Imaging (MGH), Harvard Medical School (HMS)
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BrainMap: Nonlinear fields for diffusion and point of care imaging
2026-01-07 12:00 - 13:00
Speaker: Dr. Gig Galiana, PhD — Yale School of Medicine

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BrainMap: The future of concurrent TMS-fMRI: towards reproducible and reliable acquisitions with the RF Cap
2026-01-14 12:00 - 13:00
Speaker: Prof. Lucia Navarro de Lara, Ph.D. — Athinoula A. Martinos Center for Biomedical Imaging

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BrainMap: Generalizable deep learning for neuroimage analysis
2026-01-21 12:00 - 13:00
Speaker: — Dr. Malte Hoffmann, Athinoula A. Martinos Center for Biomedical Imaging

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