Associate Professor of Radiology

Email: hjacobs@nmr.mgh.harvard.edu

Further Information

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Recent Publications

• Smegal LF, Baillet M, Schneider C, Jutten RJ, Boyle R, Rentz DM, Johnson KA, Sperling RA, Papp KV, Jacobs HIL. Lower locus coeruleus integrity is associated with diminished practice effects in clinically unimpaired older individuals. Neurobiol Aging. 2025 Apr 26. 152:13-24
• Tristão-Pereira C, Langella S, Sanchez JS, Malotaux V, He B, Alcina J, Martinez JE, Rubinstein Z, Baena A, Vila-Castelar C, Giudicessi A, Ramirez Gomez L, Ramos C, Vasquez D, Aguillon D, Jacobs HIL, Sperling RA, Johnson K, Gatchel JR, Quiroz YT. Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2025 Mar 20. 17(1):64
• Coughlan GT, Rubinstein Z, Klinger H, Lopez KA, Hsieh S, Boyle R, Seto M, Townsend D, Mayblyum D, Thibault E, Jacobs HIL, Farrell M, Rabin JS, Papp K, Amariglio R, Baker S, Lois C, Rentz D, Price J, Schultz A, Properzi M, Johnson K, Sperling R, Buckley RF. Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer's disease. Sci Adv. 2025 Mar 07. 11(10):eadt1288
• Coughlan GT, Klinger HM, Boyle R, Betthauser TJ, Binette AP, Christenson L, Chadwick T, Hansson O, Harrison TM, Healy B, Jacobs HIL, Hanseeuw B, Jonaitis E, Jack CR, Johnson KA, Langhough RE, Properzi MJ, Rentz DM, Schultz AP, Smith R, Seto M, Johnson SC, Mielke MM, Shirzadi Z, Yau WW, Manson JE, Sperling RA, Vemuri P, Buckley RF. Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis. JAMA Neurol. 2025 Mar 03.
• Van Egroo M, Beckers E, Ashton NJ, Blennow K, Zetterberg H, Jacobs HIL. Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer's disease pathology. Alzheimers Res Ther. 2024 Dec 30. 16(1):277