Associate Professor of Radiology

Email: hjacobs@nmr.mgh.harvard.edu

Further Information

---

Recent Publications

• Jacobs HIL. The monoaminergic systems as drivers of Alzheimer's disease pathophysiology and symptomatology. Curr Opin Neurol. 2026 Apr 01. 39(2):192-199
• Patsyuk Y, Van Egroo M, Beckers E, Koops EA, Ashton NJ, Janelidze S, Blennow K, Hansson O, Zetterberg H, Poser BA, Jacobs HIL. Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein. Alzheimers Dement. 2025 Dec. 21(12):e70915
• Demsey LL, Burch D, Lin E, Quach D, Podvin S, Boyarko B, Levey AI, Weinshenker D, Edland S, Galasko D, Jacobs H, Bang A, Neil A, Silverman J, Feldman HH, Hook V. Atomoxetine Drug Properties for Repurposing as a Candidate Alzheimer's Disease Therapeutic Agent. ACS Pharmacol Transl Sci. 2025 Nov 14. 8(11):3757-3772
• Zide BS, Gagliardi G, Jacobs HIL, Gatchel JR, Quiroz YT, Marshall GA, Rentz DM, Johnson KA, Sperling RA, Vannini P, Donovan NJ. Living Alone, Early Tau Pathology, and Loneliness in Cognitively Unimpaired Older Adults During the COVID-19 Pandemic. Am J Geriatr Psychiatry. 2025 Sep 20.
• Townsend DL, Properzi MJ, Betthauser TJ, Klinger HM, Boyle R, Coughlan G, Hanseeuw BJ, Yang HS, Cody KA, Amariglio RE, Farrell M, Jacobs HIL, Shirzadi Z, Yau WY, Price JC, Chhatwal J, Rentz DM, Johnson KA, Sperling RA, Schultz AP, Buckley RF. Estimating the preclinical Alzheimer's disease course with multimodal data. Alzheimers Dement. 2025 Sep. 21(9):e70658