Professor of Psychiatry

Email: dholt@partners.org

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Recent Publications

• Levitt JJ, Zhang F, Vangel M, Nestor PG, Rathi Y, Cetin-Karayumak S, Kubicki M, Pasternak O, Coleman MJ, Lewandowski KE, Holt DJ, Keshavan M, Bouix S, Öngür D, Breier A, Shenton ME, O'Donnell LJ. Diagnostic and sex effects on frontostriatal brain wiring structural organization in early psychosis affective subjects compared to healthy controls. Mol Psychiatry. 2026 11. 31(11):6498-6509
• Clauss JA, Zhi D, Perdomo SA, Dear R, Kunitoki K, Hughes DE, Blum AT, Kane KA, Elyounssi S, Cooper B, Laurent E, Bazer O, Vinke LN, O'Dor SL, Flook EA, Linnman C, Kritzer-Cheren MD, Holt DJ, Lee PH, Dunn EC, Lee H, Satterthwaite TD, Doyle AE, Barch DM, Gilman JM, Vértes PE, Bullmore ET, Roffman JL. Inflections in adolescent cortical maturation signal psychopathology risk. bioRxiv. 2026 Oct 11.
• Seitz-Holland J, Haaf M, Mendes-Silva AP, Penzel N, Berberich C, Bouix S, Coleman MJ, Kotler E, Kim N, Burdick KE, Kotov R, Falkai P, Vangel M, Leicht G, Mulert C, Kircher T, Lewandowski KE, Holt D, Keshavan MS, Öngür D, Breier A, Shenton ME, Arnold SE, Diniz BS, Kubicki M. Senescence-associated secretory phenotype proteins and inflammatory pathways are involved in psychosis: A transdiagnostic study using the Human Connectome Project for early psychosis (HCP-EP) data. Brain Behav Immun. 2026 Sep 20. 139:107023
• Mandeville JB, Barbour T, Qin Q, Gallagher E, Bass I, Deng HP, Holt D, Sander CY. Robust changes in brain function require high D2 receptor occupancy by prochlorperazine: an imaging correlate for the antipsychotic therapeutic window. Neuropsychopharmacology. 2026 Sep 18.
• Bittner RA, Holt DJ. Understanding Resilience in Psychosis: An Emerging Field. Schizophr Bull. 2026 Aug 20. 52(5)