Instructor in Radiology

Email: jriphagen@mgh.harvard.edu

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Recent Publications

• Prokopiou PC, Van Egroo M, Riphagen JM, Baillet M, Ashton NJ, Janelidze S, Sperling RA, Johnson KA, Blennow K, Hansson O, Zetterberg H, Jacobs HIL. Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine-related dysfunction on tau and its impact on cognition. Alzheimers Dement. 2026 Aug. 22(8):e71703
• Engels-Domínguez N, Riphagen JM, Van Egroo M, Koops EA, Smegal LF, Becker JA, Prokopiou PC, Bueichekú E, Kwong KK, Rentz DM, Salat DH, Sperling RA, Johnson KA, Jacobs HIL. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Ann Neurol. 2024 10. 96(4):650-661
• Engels-Domínguez N, Koops EA, Hsieh S, Wiklund EE, Schultz AP, Riphagen JM, Prokopiou PC, Hanseeuw BJ, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer's pathology: a cohort study. Alzheimers Res Ther. 2024 06 17. 16(1):129
• Beckers E, Riphagen JM, Van Egroo M, Bennett DA, Jacobs HIL. Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease. J Alzheimers Dis. 2024. 99(1):105-111
• Van Egroo M, Riphagen JM, Ashton NJ, Janelidze S, Sperling RA, Johnson KA, Yang HS, Bennett DA, Blennow K, Hansson O, Zetterberg H, Jacobs HIL. Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau. Mol Psychiatry. 2023 06. 28(6):2412-2422