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BrainMap: X-Nuclei MR Spectroscopy of the Heart: Insights from 23Na, 31P, and 13C NMR

October 8 @ 12:00 pm - 1:00 pm

Speaker: Ivan Luptak, MD, PhD, is an Associate Professor of Medicine at Boston University School of Medicine and a cardiologist at Boston Medical Center.

Bio: Ivan Luptak, MD, PhD, is an Associate Professor of Medicine at Boston University School of Medicine and a cardiologist at Boston Medical Center. His research focuses on cardiac energy metabolism, mitochondrial biology, and translational imaging approaches to hypertrophic cardiomyopathy and metabolic heart disease. His laboratory employs multi-nuclear MR spectroscopy (23Na, 31P, and 13C) in ex vivo Langendorff-perfused hearts, in vivo 31P NMR, and multi-omics analyses to define energetic dysfunction and test novel therapeutic interventions. He is PI of an NIH R01 on targeting energetics in HCM and maintains active collaborations with academic and industry partners, including recent work with the Martinos Center in hyperpolarized 13C imaging.

Abstract: Energetics and ion homeostasis are central to cardiac performance, but their direct measurement in intact tissue remains challenging. My laboratory uses multi-nuclear magnetic resonance spectroscopy — including 23Na, 31P, and non-hyperpolarized 13C — in isolated Langendorff-perfused hearts to probe energetic metabolism and substrate fluxes under stress and disease conditions. Over the past two decades, we have applied these approaches to define how mitochondrial dysfunction, impaired ATP production, and abnormal sodium handling contribute to diastolic dysfunction and impaired contractile reserve in models of hypertrophic cardiomyopathy (HCM) and metabolic heart disease. These tools have allowed us to dissect mechanisms such as oxidative inhibition of respiratory chain proteins, altered sarcomeric power efficiency, and the interplay between sodium
loading and mitochondrial energetics.

 

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Details

Date:
October 8
Time:
12:00 pm - 1:00 pm
Event Category:

Organizer

Karen Dos Santos
Email
kdossantos2@mgh.harvard.edu