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Victor Solo, PhD MGH/HST Martinos Center for Biomedical Imaging, Dept. Radiology, MGH Harvard Medical School, Boston, MA School of Electrical Engineering, UNSW, Sydney, Australia Identifying Functional Brain Networks with Conditional Independence Graphs June 1, 2023 Abstract: We discuss, in a straightforward way, some basic concepts required for the coherent construction of functional brain networks from (neuroimaging) data e.g. signals at each node of an anatomically parcellated network. The dominant approach involves correlation, and we expose its flaws. These are remedied by using partial correlation which leads to conditional independence graphs (developed in the statistics literature beginning in the 1970s) which in turn need sparsity methods to scale up to big networks. We then sketch the extension to autocorrelated signals (aka lagged correlation signals) which leads to frequency domain based functional network construction based on partial coherency and state space models. We illustrate some of the ideas with applications to real data. We have ground down the math to an absolute minimum. Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

We bid adieu to this groundbreaking piece of technology, even as we look forward to the delivery of Connectome 2.0!

Anne Berry, PhD, Brandeis University The role of monoamines in aging and Alzheimer's disease. BrainMap, May 17th, 2023 For more information about the BrainMap, visit https://www.martinos.org/education/brainmap/ https://www.martinos.org/education/scienceontap/ https://www.martinos.org/education/whyhow/ https://wis.martinos.org/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

Blaise Frederick, PhD, Harvard Medical School, McLean Hospital Using Resting State fMRI to look at everything but Neuronal Activation BrainMap, September 28th, 2022 For more information about the BrainMap, visit https://www.martinos.org/education/brainmap/ https://www.martinos.org/education/scienceontap/ https://www.martinos.org/education/whyhow/ https://wis.martinos.org/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

David Matuskey, MD, Yale University Parkinson’s disease motor severity associated with synaptic density and dopamine transporter PET BrainMap, October 12th, 2022 For more information about the BrainMap, visit https://www.martinos.org/education/brainmap/ https://www.martinos.org/education/scienceontap/ https://www.martinos.org/education/whyhow/ https://wis.martinos.org/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

Hongyu An, PhD, Washington University in St. Louis Imaging Cerebral Oxygen Metabolism BrainMap, November 2nd, 2022 For more information about the BrainMap, visit https://www.martinos.org/education/brainmap/ https://www.martinos.org/education/scienceontap/ https://www.martinos.org/education/whyhow/ https://wis.martinos.org/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!