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Dr Jonathan Jackson, Director of the MGH CARE Research Center Massachusetts General Hospital #BlackLivesMatter Women in Science, 09/10/2020 For more information about Women In Science, visit https://wis.martinos.org/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

Stefanie Blain-Moraes, School of Physical and Occupational Therapy at McGill University Adaptive Reconfiguration of Brain Networks in Disorders of Consciousness BrainMap Seminar Series, 9/9/2020 For more information about the BrainMap Seminar Series, visit https://www.martinos.org/education/brainmap/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

Viviana Siless & Paige Sparks, Athinoula A. Martinos Center for Biomedical Imaging This Science on Tap seminar focuses on the Women in Science Fall Series + Structure + Elections. For more information about the Women in Science, please visit https://wis.martinos.org/ Women in Science Fall Series + Structure + Elections Science on Tap, 9/11/2020 For more information about the Science on Tap Seminar Series, visit https://www.martinos.org/education/scienceontap/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

Dr. Bertrand Thirion, INRIA/CEA/Neurospin France Abstract: To map the neural substrate of mental function, cognitive neuroimaging relies on controlled psychological manipulations that engage brain systems associated with specific cognitive processes. In order to build comprehensive atlases of cognitive function in the brain, it must assemble maps for many different cognitive processes, which often evoke overlapping patterns of activation. Such data aggregation faces contrasting goals: on the one hand finding correspondences across vastly different cognitive experiments, while on the other hand precisely describing the function of any given brain region. In this talk I will present two analysis frameworks that tackle these difficulties and thereby enable the generation of brain atlases for cognitive function. The first one uses deep-learning techniques to extract representations—task-optimized networks—that form a set of basis cognitive dimensions relevant to the psychological manipulations.This approach does not assume any prior knowledge of the commonalities shared by the studies in the corpus; those are inferred during model training. The second one leverages ontologies of cognitive concepts and multi-label brain decoding to map the neural substrate of these concepts. Crucially, it can accurately decode the cognitive concepts recruited in new tasks. These results demonstrate that aggregating independent task-fMRI studies can provide a more precise global atlas of selective associations between brain and cognition. Bio: Bertrand Thirion is the leader of the Parietal team, part of INRIA research institute, Saclay, France, that develops statistics and machine learning techniques for brain imaging. He contributes both algorithms and software, with a special focus on functional neuroimaging applications. He is involved in the Neurospin (CEA) neuroimaging center, one of the leading high-field MRI for brain imaging places. Bertrand Thirion is also head of the DATAIA Institute that federates research on AI, data science and their societal impact in Paris-Saclay University. He has recently been appointed as member of the expert committee in charge of advising the government during the Covid-19 pandemic. From fMRI Mega-analyses to Universal Representations of Cognition BrainMap, 09/02/2020 For more information about the BrainMap Seminar Series, visit https://www.martinos.org/education/brainmap/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!

Dr. Ravi Menon, Professor of Medical Biophysics, Medical Imaging, Physics and Psychiatry at Western University, Canada Abstract: Marmosets are small New World primates that could become an important preclinical animal model for studying human brain diseases. A critical step in the development of marmosets as a viable model for human brain dysfunction is to characterize brain networks that are homologous with human network topologies. It’s also important to understand if these network topologies are shared with rodents, the model in which the vast majority of preclinical work has been performed to date. I will review our MRI developments that have allowed us to develop awake, behaving marmoset imaging at 9.4T. I’ll then discuss some results from awake fMRI studies of these animals including recent work where we compare whole-brain functional connectivity fingerprinting of the medial frontal cortex (MFC) in rodents, marmosets and humans. We observe a remarkably similar intrinsic functional organization of the MFC across the three species, but clear differences between rodent and primate MFC whole-brain connectivity. In contrast to the common proposal that the rat MFC is functionally analogous with the primate lateral (LFC), our results demonstrate clear differences between the rodent MFC and primate LFC interareal functional connectivity. This cautions the use of rodents for behaviours and disorders involving the dorsolateral prefrontal cortex in humans. Bio: Dr. Ravi Menon is a Professor of Medical Biophysics, Medical Imaging, Physics and Psychiatry at Western University, where he is also a member of the Graduate Program in Neuroscience and the Graduate Program in Biomedical Engineering and Founding Director of Western’s Centre for Functional and Metabolic Mapping (CFMM), Canada’s only ultra-high field MRI facility. He holds a Ph.D. in Medicine from the University of Alberta (1990), a M.Sc.(A) in Medical Physics from McGill University and a B.Sc. (Hons) in Physics from the University of British Columbia. He did his postdoctoral work in the laboratory of Dr. Kamil Ugurbil at the University of Minnesota. He was awarded one of the inaugural Canada Research Chairs in 2001. He has held grants from a broad spectrum of national and international funding agencies including a CIHR Foundation Grant in 2016. He currently serves as co-Scientific Director of BrainsCAN, a $66M grant from the Canada First Research Excellence Fund. He is twice an awardee of Canada’s Top 40 under 40 program and one of 20 recipients of the Young Explorers Medal from the Canadian Institute for Advanced Research. In 2015, he was elected as a Senior Fellow of the International Society for Magnetic Resonance in Medicine and the Canadian Academy of Health Sciences. In 2019 he was inducted as a Fellow of the Royal Society of Canada. He has served in numerous advisory capacities, including 7 years on the Canada Gairdner Foundation and the Board of Scientific Councilors of NIMH/NIH. He served for 7 years (the last 4 as Chair) on the Institute Advisory Board of the Institute for Neuroscience, Mental Health and Addiction of the CIHR. He currently serves on the Board of the Brain Canada Foundation along with several of Canada’s leading Philanthropists. Awake, Behaving Functional Imaging of the Marmoset at 9.4 T BrainMap Seminar, 08/26/2020 For more information about the BrainMap Seminar Series and organizers, visit https://www.martinos.org/education/brainmap/ Athinoula A. Martinos Center for Biomedical Imaging https://www.martinos.org/ Follow @MGHMartinos on Facebook, Instagram + Twitter!