Dr. Magnain is an Instructor in Radiology at Harvard Medical School and Assistant in Physics at Massachusetts General Hospital in Boston. Throughout her career, she has strived to apply optical imaging to various domains, from cultural heritage to the biomedical science, and has developed experimental set-ups, optical simulations, and image analysis software.

In 2011, Dr. Magnain joined the Athinoula A. Martinos Center for Biomedical Imaging as a postdoctoral fellow to initiate a collaboration between the Optics Division and the Laboratory for Computational Neuroimaging. She was the first to apply optical coherence tomography and microscopy (OCT/OCM) to image the human brain postmortem to visualize its cellular and fiber organizations. Dr. Magnain is involved in improving the imaging system, automating the acquisition, and writing image processing software. She also dedicates significant time to comparing and validating OCT/OCM data with gold standard methods used by collaborators, mostly doctors, neuroanatomists, and neuropathologists.


PhD in Physics, Universite Pierre et Marie Curie, France

Select Publications

1. Magnain C, Augustinack JC, Tirrell L, Fogarty M, Frosch MP, Boas D, Fischl B,  Rockland KS. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21. Brain Struct Funct. 2019 Jan;224(1):351-362.

2. Magnain C, Augustinack JC, Konukoglu E, Frosch MP, Sakadžić S, Varjabedian A, Garcia N, Wedeen VJ, Boas DA, Fischl B. Optical coherence tomography visualizes neurons in human entorhinal cortex. Neurophotonics. 2015 Feb 9;2(1):015004.

3. Magnain C, Augustinack JC, Reuter M, Wachinger C, Frosch MP, Ragan T, Akkin T, Wedeen VJ, Boas DA, Fischl B. Blockface histology with optical coherence tomography: a comparison with Nissl staining. Neuroimage. 2014 Jan 1;84:524-33.


2019: Chan Zuckerberg Initiative Imaging Scientist grantee