Dr. Gale’s research applies chemistry to solve unmet challenges in radiology and biomedical imaging. His team is currently focused on developing transition metal complexes as MRI contrast agents.
One project is focused on developing complexes of divalent manganese (Mn2+) as an alternative to commercially available gadolinium (Gd) based contrast agents (GBCAs). GBCAs are the standard of care for contrast enhanced MRI examinations to diagnose abnormalities in soft tissues and blood vessels, but recent concerns over long-term Gd retention and delayed toxicity have led to apprehension in the radiologic community and triggered new regulatory scrutiny. Like Gd, the Mn2+ ion is a potent relaxation agent that leads to strong MR signal enhancement. Unlike Gd, Mn is a nutritional element that can be processed and excreted by humans. Dr. Gale’s Mn2+-based contrast agents are rationally designed to function as direct replacements for commercial GBCA formulations.
A second project capitalizes on the transition metal properties of Mn and iron (Fe) to develop biochemically responsive MRI contrast agents. Rationally designed complexes of Mn2+ and Fe3+ can function as strong relaxation agents, whereas complexes of their sister Mn3+ and Fe2+ oxidation states are generally very poor relaxation agents. Switching between metal oxidation states provides a mechanism by which MR contrast can be turned “off” or “on” selectively in the presence of biochemical stimuli. Dr. Gale’s group is currently developing redox active complexes of Mn and Fe as sensors for reactive oxygen species, various oxidase
PhD in Chemistry, University of Georgia
1. Wang H, Jordan VC, Ramsay IA, Sojoodi M, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex. J Am Chem Soc. 2019 Apr 10;141(14):5916-5925.
2. Wang J, Wang H, Ramsay IA, Erstad DJ, Fuchs BC, Tanabe KK, Caravan P, Gale EM. Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation. J Med Chem. 2018 Oct 11;61(19):8811-8824.
3. Gale EM, Atanasova IP, Blasi F, Ay I, Caravan P. A Manganese Alternative to Gadolinium for MRI Contrast. J Am Chem Soc. 2015 Dec 16;137(49):15548-57.
2019: Named “One to Watch” by the Society for Nuclear Medicine and Molecular