Dr. Matt Rosen is a physicist, tool-builder and inventor whose research bridges the spectrum from fundamental physics to applied bioimaging work in the field of MRI. He established the Low-Field MRI and Hyperpolarized Media Laboratory at the Athinoula A. Martinos Center for Biomedical Imaging to focus on the continued development of new hyperpolarization methods and MRI-based tools.

The Rosen Lab focuses on new methods and tools to enable unconventional approaches to MRI scanner construction. This includes the development of new acquisition strategies for robust ultra-low magnetic field implementations of MRI focused on brain imaging. The laboratory also explores opportunities provided by hyperpolarization including in vivo Overhauser DNP, SABRE and spin-exchange optical pumping. The lab creates new quantitative strategies for the acquisition and the reconstruction of highly undersampled imaging data including neural network deep learning-based approaches such as AUTOMAP that leverage low-cost scalable-compute. Dr. Rosen co-directs the Center for Machine Learning at the Martinos Center.

Education

PhD in Physics, University of Michigan, Ann Arbor

Select Publications

1. Zhu B, Liu JZ, Cauley SF, Rosen BR, Rosen MS. Image reconstruction by domain-transform manifold learning. Nature. 2018 Mar 21;555(7697):487 492.

2. Waddington DEJ, Sarracanie M, Zhang H, Salameh N, Glenn DR, Rej E, Gaebel T, Boele T, Walsworth RL, Reilly DJ, Rosen MS. Nanodiamond-enhanced MRI via in situ  hyperpolarization. Nat Commun. 2017 Apr 26;8:15118.

3. Sarracanie M, LaPierre CD, Salameh N, Waddington DEJ, Witzel T, Rosen MS. Low-Cost High-Performance MRI. Sci Rep. 2015 Oct 15;5:15177.

Highlights

Co-founder: Hyperfine Research, BlinkAI

Website

Low-field MRI and Hyperpolarized Media Laboratory