I am a medical oncologist with interests in using machine learning and Omics to develop precision-based treatment paradigms for cancer patients. I have a special interest in central nervous system metastases, and my laboratory efforts leverage Omics-based techniques, medical imaging, and machine learning to define and target genomic and metabolic vulnerabilities for these tumors. My hope is that these efforts will result in newer and smarter ways to treat these difficult diseases.
MD, Medical College of Georgia
1. Brastianos PK*, Kim AE*, Wang N, Lee EQ, Ligibel J, Cohen JV, Chukwueke UN, Mahar M, Oh K, White MD, Shih HA, Forst D, Gainor JF, Heist RS, Gerstner ER, Batchelor TT, Lawrence D, Ryan DP, Iafrate AJ, Giobbie-Hurder A, Santagata S, Carter SL, Cahill DP, Sullivan RJ. Palbociclib demonstrates intracranial activity in progressive brain metastases harboring cyclin-dependent kinase pathway alterations. Nat Cancer 2, 498-502 (2021). (* denotes equal authorship)
2. Prakadan SM*, Alvarez-Breckenridge CA*, Markson SC*, Kim AE, Klein RH, Nayyar N, Navia AW, Kuter BM, Kolb KE, Bihun I, Mora JL, Bertalan MS, Shaw B, White M, Kaplan A, Stocking JH, Wadsworth MH, Lee EQ, Chukwueke U, Wang N, Subramanian M, Rotem D, Cahill DP, Adalsteinsson VA, Miller JW, Sullivan RJ, Carter SL, Brastianos PK, Shalek AK. Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases. Nature Comms 2021 Oct 12; 12(1):5955. (* denotes equal authorship)
3. Brastianos PK*, Kim AE*, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, Chukwueke U, Forst DA, Arrillaga-Romany IC, Dietrich J, Corbin Z, Moliterno J, Baehring J, White M, Lou KW, Larson J, de Sauvage MA, Evancic K, Mora J, Nayyar N, Loeffler J, Oh K, Shih HA, Curry WT, Cahill DP, Barker FG, Gerstner ER, Santagata S. Phase 2 study of pembrolizumab in patients with recurrent and high-grade meningiomas. Nature Comms 2022 Mar 14;13(1):1325. (* denotes equal authorship)
4. Kim AE, Nieblas-Bedolla E, de Sauvage MA, Brastianos PK. Leveraging translational insights towards precision medicine approaches for brain metastases. Nat Cancer. In Press.
Damon Runyon Cancer Research Foundation Physician Scientist Award
American Association of Cancer Research Breast Cancer Research Fellowship
American Brain Tumor Association Basic Research Fellowship
American Society of Clinical Oncology Young Investigator Award
American Society of Clinical Investigation Emerging-Generation Award