Dr. Juttkonda’s research focuses on the development of imaging methods for measuring cerebral hemo-metabolic function and the translation of these methods for characterizing microvascular health in cerebrovascular diseases. The immediate goal is to employ a multidisciplinary approach to elucidate the physiological consequences of cerebral small vessel disease (CSVD) in aging and dementia. CSVD refers to a collection of pathological processes that affects small vessels in the brain, and the presence of white matter lesions indicative of CSVD has been associated with accelerated aging and cognitive dysfunction. His work focuses on (i) developing MRI-based approaches, including at high field, for studying relevant hemodynamic function, and (ii) investigating hemodynamic function, particularly in white matter, in populations at elevated risk for CSVD with the goal of identifying biomarkers of disease risk.

Education

PhD in Biomedical Engineering, The University of North Carolina at Chapel Hill

Select Publications

1. Juttukonda MR, Donahue MJ, Davis LT, Gindville MC, Lee CA, Patel NJ, et al. Preliminary evidence for cerebral capillary shunting in adults with sickle cell anemia. J Cereb Blood Flow Metab. 2019;39(6):1099-110.

2. Juttukonda MR, Jordan LC, Gindville MC, Davis LT, Watchmaker JM, Pruthi S, et al. Cerebral hemodynamics and pseudo-continuous arterial spin labeling considerations in adults with sickle cell anemia. NMR Biomed. 2017;30(2).

3. Juttukonda MR, Mersereau BG, Chen Y, Su Y, Rubin BG, Benzinger TLS, et al. MR-based attenuation correction for PET/MRI neurological studies with continuous-valued attenuation coefficients for bone through a conversion from R2* to CT-Hounsfield units. Neuroimage. 2015;112:160-8.

Highlights

2019: American Heart Association Career Development Award

Website

Brain Aging and Dementia (BAnD) Laboratory