Dr. Juttukonda’s research interests are in studying the balance between hemodynamic and metabolic function in the human brain as well as in the translation of these methods for characterizing microvascular health in cerebrovascular diseases. A principal objective of his work has been to develop quantitative MRI approaches, including arterial spin labeling (ASL)-based methods, for better characterizing cerebral hemodynamic and metabolic function. A central focus is the application of these methods for studying imaging-based biomarkers of impairment due to cerebrovascular diseases as well as markers of response to disease-modifying therapies, including as part of longitudinal human trials. Current work in the group involves elucidating the impact of aging on the microvasculature in the brain, particularly in the white matter, and how cerebrovascular health may portend risk for accumulating white matter damage that contributes to the burden of cognitive decline in aging and Alzheimer’s disease (AD).

Education

PhD in Biomedical Engineering, The University of North Carolina at Chapel Hill

Select Publications

1. Juttukonda MR, Li B, Almaktoum R, Stephens KA, Yochim KM, Yacoub E, Buckner RL, Salat DH. Characterizing cerebral hemodynamics across the adult lifespan with arterial spin labeling MRI data from the Human Connectome Project-Aging. Neuroimage. 2021 Apr 15;230:117807. doi: 10.1016/j.neuroimage.2021.117807. Epub 2021 Jan 29. PMID: 33524575; PMCID: PMC8185881.

2. Juttukonda MR, Donahue MJ, Waddle SL, Davis LT, Lee CA, Patel NJ, Pruthi S, Kassim AA, Jordan LC. Reduced oxygen extraction efficiency in sickle cell anemia patients with evidence of cerebral capillary shunting. J Cereb Blood Flow Metab. 2021 Mar;41(3):546-560. doi: 10.1177/0271678X20913123. Epub 2020 Apr 11. PMID: 32281458; PMCID: PMC7922746.

3. Juttukonda MR, Davis LT, Lants SK, Waddle SL, Lee CA, Patel NJ, Jordan LC, Donahue MJ. A Prospective, Longitudinal Magnetic Resonance Imaging Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis. J Magn Reson Imaging. 2021 Sep;54(3):912-922. doi: 10.1002/jmri.27605. Epub 2021 Mar 24. PMID: 33763922; PMCID: PMC8675276.

Highlights

2021: Mentored Research Scientist Development (K01) Award, National Institutes of Health / National Institute on Aging

2019: American Heart Association Career Development Award

Website

Cerebrovascular Aging and Spin Labeling (CASL) Laboratory