Dr. Sakadzic obtained his Ph.D. with Dr. Lihong Wang at Texas A&M University and completed his postdoctoral training with Dr. David Boas at the Massachusetts General Hospital. His group is developing state-of-the-art optical microscopy imaging technologies and utilizing them to better understand oxygen delivery and consumption on microvascular scales. The goal of these research efforts is to better understand neurovascular coupling in health and disease, to facilitate improvement and development of treatments of brain conditions, and to enable new imaging biomarkers and more quantitative interpretation of macroscopic imaging modalities.


PhD in Biomedical Engineering, Texas A&M University, College Station, Texas

Select Publications

1. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997.

2. Li B, Esipova TV, Sencan I, Kiliç K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Østergaard L, Devor A, Boas DA, Vinogradov SA, Sakadžic S. More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction. Elife. 2019 07 15; 8. PMID: 31305237.

3. Sencan I, Esipova T, Kiliç K, Li B, Desjardins M, Yaseen MA, Wang H, Porter JE, Kura S, Fu B, Secomb TW, Boas DA, Vinogradov SA, Devor A, Sakadžic S. Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation. J Cereb Blood Flow Metab. 2022 03; 42(3):510-525. PMID: 325156