Dr. Mandeville focuses on understanding relationships between imaging signals and physiology and using this information to improve information content derived from noninvasive neuroimaging. Research leverages all aspects of multimodal imaging to understand functional imaging methods and the brain; work includes characterization of imaging biomarkers, improvement of functional imaging capabilities (e.g., contrast to noise ratios), and development of optimal analysis strategies. Prior work included development of contrast-enhanced fMRI and quantitative models of BOLD signal, and more recent efforts have focused on combined PET/fMRI to understand occupancy-function relationships and to quantitatively model PET and fMRI signals in the context of pharmacological stimuli.

Education

PhD in Physics, University of Illinois Urbana-Champaign

Select Publications

1. Mandeville JB, Marota JJ, Ayata C, Zaharchuk G, Moskowitz MA, Rosen BR,
Weisskoff RM. Evidence of a cerebrovascular postarteriole windkessel with
delayed compliance. J Cereb Blood Flow Metab. 1999; 19(6):679-689.

2. Mandeville JB. IRON fMRI measurements of CBV and implications for BOLD
signal. NeuroImage 2012; 62(2): 1000-1008.8-2385.

3. Sander CY, Hooker JM, Catana C, Normandin MD, Alpert NM, Knudsen GM,
Vanduffel W, Rosen BR, Mandeville JB. Neurovascular coupling to D2/D3
dopamine receptor occupancy using simultaneous PET/functional MRI. PNAS 2013;
110(27): 11169-11174.7.

Highlights

Adler Award for Outstanding graduate nuclear physics research at University
of Illinois at UC

Peter Demos Award for Outstanding Ph.D. Thesis from Bates Laboratory,
Massachusetts Institute of Technology

Patent: Method for diagnosing neurological, neurodegenerative, and
psychiatric diseases by MRI using contrast agents with high magnetic
susceptibility and extended plasma half life. (Co-inventors Bruce Jenkins,
and Freidrich Cavagna)