Randy Buckner

Professor

Buckner Laboratory (Director)
Division of Psychiatric Neuroimaging

randy_buckner@harvard.edu
617-724-5652

Tagged:Aging, Alzheimer's Disease, Brain, Brain Mapping, Data Science, Diffusion MRI, fMRI, FreeSurfer, High-field Imaging, MRI, PET, Software Development, TMS

Randy Buckner, PhD, is the Sosland Family Professor of Psychology and of Neuroscience at Harvard University affiliated with the Center for Brain Science and Director of the Psychiatric Neuroimaging Research Division at the Massachusetts General Hospital. He has been faculty of the Athinoula A. Martinos Center for Biomedical Imaging for over twenty years. Trained in cognitive psychology and systems neuroscience, Dr. Buckner’s work has centered on understanding how the brain supports high-level cognition and why dysfunction arises in illness.

Education

PhD in Neuroscience, Washington University

Select Publications

1. Choi EY, Yeo BT, Buckner RL. The organization of the human striatum estimated by intrinsic functional connectivity. J Neurophysiol. 2012 Oct;108(8):2242-63.

2. Braga RM, Buckner RL. Parallel Interdigitated Distributed Networks within the Individual Estimated by Intrinsic Functional Connectivity. Neuron. 2017 Jul 19;95(2):457-471.e5.

3. Buckner RL, Margulies DS. Macroscale cortical organization and a default-like apex transmodal network in the marmoset monkey. Nat Commun. 2019 Apr 29;10(1):1976.

Highlights

2007: Troland Research Award, National Academy of Sciences

2010: MetLife Award for Medical Research, MetLife Foundation

2018: MGH Psychiatry Department Mentorship in Research Award

Websites

Buckner Laboratory
Division of Psychiatric Neuroimaging

Dara Manoach

Professor

Sleep,Cognition and Neuropsychiatry (SCAN) Lab (Director)

dara.manoach@mgh.harvard.edu

Tagged:Autism, Brain, Clinical, Diffusion MRI, EEG, fMRI, MEG, MEG/EEG source localization, MRI, Multimodal Imaging, Schizophrenia

Dr. Manoach is a clinically licensed neuropsychologist and an experimental psychologist by training. She has dedicated her career to understanding the neural basis and nature of fundamental cognitive deficits in neuropsychiatric disorders, particularly schizophrenia and autism. Although sleep plays a critical role in cognition, abnormal sleep has generally been overlooked as a potential contributor to cognitive disability. This oversight is important as effective treatments for cognitive disability are lacking and abnormal sleep is a potential treatment target.

Dr. Manoach’s group demonstrated that patients with schizophrenia have impaired sleep-dependent memory and linked this deficit to a profound reduction in sleep spindles, which are brain waves that enhance memory during sleep. Her group has also reported spindle deficits in antipsychotic-naïve patients with schizophrenia and their 1st° relatives, suggesting that spindle deficits are fundamental to schizophrenia and index genetic vulnerability. Her group is now using genetic information to identify the brain bases of spindle deficits and to develop and test treatments for spindle-related cognitive deficits. The goal of Dr. Manoach’s research program is to further the understanding, treatment and prevention of schizophrenia.

Education

PhD in Psychology, Harvard University

Select Publications

1. Manoach DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr Res. 2003 Apr 1;60(2-3):285-98.

2. Agam Y, Hämäläinen MS, Lee AK, Dyckman KA, Friedman JS, Isom M, Makris N, Manoach DS. Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17556-61.

3. Manoach DS, Stickgold R. Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia. Annu Rev Clin Psychol. 2019 May 7;15:451-479.

Highlights

2018: Australia-Harvard Fellow, Harvard Club of Australia Foundation

2019-2024: MGH Research Scholar, Executive Committee on Research, MGH

Website

Sleep,Cognition and Neuropsychiatry (SCAN) Lab

Randy Hirschtick

Professor

A1 Pain Imaging Lab

rgollub@partners.org

Tagged:Acupuncture, Brain, Brain Mapping, Clinical, Data Science, Diffusion MRI, fMRI, Functional Magnetic Resonance Imaging, Magnetic Resonance Imaging, Meditation, MRI, Pain, PET-MRI, Schizophrenia

Randy Hirschtick, MD, PhD, is Professor of Psychiatry at Harvard Medical School and Clinical Professor of Psychiatry with a secondary appointment in Radiology at Massachusetts General Hospital, where she serves as the Associate Director of Translational Research in the Neuroimaging Research Program. She has been on faculty at HMS/MGH since 1993.

The focus of Dr. Hirschtick’s research is at the interface between the technological advancement of neuroimaging acquisition and analysis methods and their application to basic and clinical neuroscience. One of the first investigators to use fMRI to study healthy and disordered human brains, she has contributed to the development and dissemination of best practices for using those technologies through publication of exemplar research studies conducted with collaborators in multiple domains. Studies originating in her lab have used multimodal magnetic resonance neuroimaging acquisitions, including BOLD fMRI, ASL, diffusion and structural scans, to investigate pain and modulation of pain by placebo and integrative medical treatments in healthy subjects and in patients suffering from chronic pain disorders.

Dr. Hirschtick also has an active research program in the domain of neuroimaging informatics that focuses on the within- and cross-site calibration and validation of neuroimaging data vital to the development of viable biomarkers as well as on technical and logistical efforts to aggregate large datasets for research. She has made multiple contributions including as site PI for a publicly available multi-site clinical imaging investigation of schizophrenia and as a co-developer of the Medical Imaging Informatics Bench to Bedside (mi2b2) workbench that enables images acquired during the conduct of clinical care to be used for secondary research purposes. This unique resource for accessing clinical images is integrated directly into the Research Patient Data Registry (RPDR) at Partners Healthcare institutions. She currently has several projects underway using mi2b2 acquired images for the study of MRI metrics of healthy brain development and detection of neonatal brain damage.

Education

MD (MSTP), Duke University School of Medicine
PhD in Pharmacology, Duke University

Select Publications

1. Kong J, White N, Kwong K, Vangel M, Rosman IS, Gracely RH, et al. Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Human Brain Mapping. 2006;27:715-21.

2. Gollub RL, Shoemaker JM, King MD, White T, Ehrlich S, Sponheim SR, et al. The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics. 2013;11(3):367-88.

3. Ou Y, Zöllei L, Retzepi K, Castro V, Bates SV, Pieper S, et al. Using clinically-acquired MRI to construct age-specific ADC atlases: quantifying spatiotemporal ADC changes from birth to 6-year old. Human Brain Mapping. 2017;88(20):1912-8.

Highlights

Dr. Hirschtick has a long-standing commitment to biomedical education. A member of the affiliate faculty of the Harvard Massachusetts Institute of Technology division of Health Sciences Technology (HST), she serves as Co-Training Director of the HST Neuroimaging Training Program and was the originating Course Director for HST.583 fMRI Data Acquisition and Analysis.

Website

A1 Pain Imaging Lab

Julie Price

Professor

The Price Lab (Director)

jcprice@mgh.harvard.edu

Tagged:Aging, Depression, Diabetes, Eating Disorders, MR-PET, Neurodegeneration, PET, Positron Emission Tomography, Quantitative PET, Sleep, Traumatic Brain Injury

One of the Center’s newest senior faculty members, Julie Price, PhD, brings to the Martinos community a wealth of experience with quantitative positron emission tomography (PET). With this technique, researchers study the dynamics of the PET radiotracer in vivo in order to obtain absolute measurement of functional processes: the binding capacity of neuroreceptors, glucose metabolism, blood flow, enzyme activity and more.

Quantitative PET studies have played an important role in improving our understanding of the physiology of the living human brain in both health and disease. A number of application areas benefit from such studies. These include healthy brain function and aging, sleep, depression, eating disorders, brain injury and diabetes, among other areas. Dr. Price’s work currently focuses on neurodegeneration, simultaneous PET-MR and early risk factors for Type 2 Diabetes.

Website

The Price Lab

Bruce Rosen

Professor

Director, Athinoula A. Martinos Center for Biomedical Imaging

BRROSEN@mgh.harvard.edu

Tagged:Diffusion MRI, EEG, Electroencephalography, fMRI, Functional Magnetic Resonance Imaging, Magnetic Resonance Imaging, Magnetoencephalography, MEG, Molecular Imaging, MR-PET, MRI, Multimodal Imaging, Optical Imaging, Optics, PET, Positron Emission Tomography, Spectroscopy, TMS, Transcranial Magnetic Stimulation

Bruce Rosen, MD, PhD, is Director of the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital and the Laurence Lamson Robbins Professor of Radiology at Harvard Medical School. He received his MD degree from Hahnemann Medical College in Philadelphia in 1982 and his PhD degree from MIT in 1984, and subsequently completed an internship and residency at Mass General and research fellowships at Mass General and the Harvard-MIT Division of Health Sciences and Technology (HST). He joined the faculty of Harvard Medical School in 1987.

Dr. Rosen has received numerous awards in recognition of his contributions to biomedical imaging, including the Outstanding Researcher award from the Radiological Society of North America (RSNA) and the Rigshospitalet’s International KFJ Prize from the University of Copenhagen/Rigshospitalet. He is a Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM); a Gold Medal winner from ISMRM for his contributions to the field of functional neuroimaging; a Fellow of the American Institute for Medical and Biological Engineering; and a member of the Institute of Medicine of the National Academies, the American Academy of Arts and Sciences, and the National Academy of Inventors.

Among his many achievements in the biomedical sciences, Dr. Rosen is a pioneer in the field of functional neuroimaging. In the early 1990s, he oversaw development of the technique functional magnetic resonance imaging (fMRI), which measures the hemodynamic and metabolic changes associated with brain activity in both health and disease. More recently, his work has focused on the integration of fMRI data with information from other imaging modalities, including positron emission tomography (PET), magnetoencephalography (MEG) and noninvasive optical imaging. Many of the tools he has introduced are now used by research centers and hospitals around the world to study and evaluate patients with stroke, brain tumors, dementia, and neurologic and psychological disorders.

Bruce Fischl

Professor

Laboratory for Computational Neuroimaging (LCN) (Director)

fischl@nmr.mgh.harvard.edu

Tagged:Algorithm Development, Brain, Data Science, Diffusion MRI, fMRI, FreeSurfer, Functional Magnetic Resonance Imaging, Machine Learning, Magnetic Resonance Imaging, MRI, Software Development

Bruce Fischl, PhD, is a Professor of Radiology at Harvard Medical School and Director of the Laboratory for Computational Neuroimaging at the Martinos Center for Biomedical Imaging. A leader in the field of image processing and analysis, he has spearheaded the development of a range of innovative techniques to aid in generating models of neuroanatomical structures using MRI. Not least: In the late 1990s, he and his group introduced the software suite FreeSurfer, which encompasses a number of tools to aid in the analysis of data from the highly folded cortex. Today, the software boasts nearly 33,000 active licenses, with users around the world applying it to a host of basic science and clinical problems.

Website

Laboratory for Computational Neuroimaging

Peter Caravan

Professor

Institute for Innovation in Imaging (I³) (Co-director)
The Caravan Lab (Director)

caravan@nmr.mgh.harvard.edu
617-643-0193

Peter Caravan, PhD, is co-director of the Institute for Innovation in Imaging (I³) at Massachusetts General Hospital and a Professor of Radiology at Harvard Medical School. He leads a multidisciplinary and translational molecular imaging lab (the Caravan Lab) focused on the invention of novel molecular probes and their broad applications in cardiovascular, pulmonary, renal and hepatic diseases, as well as in cancers. His research spans novel chemistry technologies from advanced MRI and PET imaging in animal models to applications in patient populations. He holds Investigational New Drug (IND) applications for a fibrin-targeted PET tracer and a collagen-targeted PET tracer that are currently being evaluated in 6 clinical trials. He has invented molecular probes specific to fibrogenesis, acidosis, inflammation and thrombosis, as well as gadolinium-free MR contrast agents.

Dr. Caravan received a PhD in Inorganic Chemistry from the University of British Columbia. Following postdoctoral work at the EPFL (Switzerland), he spent 9 years at Epix Pharmaceuticals developing tissue-specific and responsive MRI contrast agents, one of which, gadofosveset, was approved by the FDA and the EMA. He co-invented EP-2104R, which was the first molecularly targeted MRI contrast agent to enter clinical trials. Since joining MGH in 2007, he has been continuously funded by the NIH.

Education

PhD in Inorganic Chemistry, University of British Columbia

Select Publications

1. Desogere P, Tapias LF, Hariri LP, Rotile NJ, Rietz TA, Probst CK, et al. Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models. Sci Transl Med. 2017;9(384).

2. Chen HH, Waghorn PA, Wei L, Tapias LF, Schuhle DT, Rotile NJ, et al. Molecular imaging of oxidized collagen quantifies pulmonary and hepatic fibrogenesis. JCI Insight. 2017;2(11).

3. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. Radiology. 2018;286(3):865-72.

4. Blasi F, Oliveira BL, Rietz TA, Rotile NJ, Naha PC, Cormode DP, et al. Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats. Arterioscler Thromb Vasc Biol. 2015;35(10):2114-21.

Highlights

Fellow of the ISMRM

Distinguished Investigator, Academy of Radiology Research

2019 Recipient of the Torsten Almén Award

2020 Recipient of the MGH Thrall Mentoring Award

Over 15 issued patents, over 140 peer-reviewed journal articles

Websites

Institute for Innovation in Imaging (I³)
The Caravan Lab

Maria Angela Franceschini

Professor

Optics @ Martinos

mfranceschini@mgh.harvard.edu
617-726-4024

Maria Angela Franceschini, PhD, is widely recognized as a leader in the field of diffuse optical imaging in both neuroscience and clinical neuro-monitoring applications. Her research interests lie mainly in the development of novel optical imaging methods to achieve a deeper understanding of the brain and to impact the clinical management of patients, with a specific focus on investigating and quantifying oxygen delivery to and consumption by the brain in health and disease. Her activities are centered on non-invasive optical measurements in humans, from hardware and theoretical development to translational applications. Her research is intrinsically interdisciplinary and translational.

Dr. Franceschini’s broad vision and mission center on the translation of near-infrared spectroscopy (NIRS) imaging devices to general use as monitors of brain health and function. This can be achieved by pushing the development of more sophisticated, accurate and comprehensive devices, by refining the modeling of the measured signal to quantifiable biomarkers and by applying the novel tools in a wide range of applications with pilot, pivotal and clinical studies. She firmly believes in the impact that optical methods will have on advancing our understanding of how the brain works in health and disease. In particular, advanced NIRS tools have the potential to change patient management when used as bedside monitors, to provide a concrete measure of brain development in children in seconds by quantifying regional oxygen metabolism, and to assess adequacy of cerebral perfusion in astronauts in space by monitoring hypertension and intracranial pressure.

Education

PhD in Physics, University of Florence, Italy

Select Publications

1. Roche-Labarbe N, Fenoglio A, Radhakrishnan H, Kocienski-Filip M, Carp SA, Dubb J, Boas DA, Grant PE, Franceschini MA. Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates. Neuroimage. 2014 Jan 15;85 Pt 1:279-86.

2. Sutin J, Zimmerman B, Tyulmankov D, Tamborini D, Wu KC, Selb J, Gulinatti A, Rech I, Tosi A, Boas DA, Franceschini MA. Time-domain diffuse correlation spectroscopy. Optica. 2016 Sep;3(9):1006-1013.

3. Roberts SB, Franceschini MA, Krauss A, Lin PY, de Sa AB, Có R, Taylor S, Brown C, Chen O, Johnson EJ, Pruzensky W, Schlossman N, Balé C, Wu KT, Hagan K, Saltzman E, Muentener P. A Pilot Randomized Controlled Trial of a New Supplementary Food Designed to Enhance Cognitive Performance during Prevention and Treatment of Malnutrition in Childhood. Curr Dev Nutr. 2017 Nov;1(11). pii: e000885.

Highlights

President Elect of the Society for Functional Near-Infrared Spectroscopy

Fellow of AIMBE and OSA

Distinguished Investigator, Academy of Radiology Research

Over 100 peer-reviewed journal articles, H-Index 57, over 15 patents

Website

Optics @ Martinos

Marco Loggia

Professor

Pain and Neuroinflammation Imaging Lab (Director)
Center for integrative Pain NeuroImaging, CiPNI (co-Director)

marco.loggia@mgh.harvard.edu
617-643-7267

Tagged:Brain, Clinical, Data Science, fMRI, FreeSurfer, Molecular Imaging, MRI, Multimodal Imaging, Neuroinflammation, Pain, PET, PET-MRI, Spectroscopy, Spine

In 2008, Marco Loggia was awarded a PhD In Neurological Sciences by McGill University in Montreal, QC (Canada). During his graduate studies, he had the opportunity to work at the Alan Edwards Centre for Research on Pain (formerly McGill Centre for Research on Pain) under the mentorship of its first director, Prof. M. Catherine Bushnell, a pioneer in the field of human pain imaging. Between 2008 and 2013, Dr. Loggia held the position of Research Fellow at Harvard Medical School, Brigham and Women’s Hospital, and Massachusetts General Hospital. As of 2013 Dr. Loggia became faculty at Harvard Medical School and Massachusetts General Hospital.

Over the past few years, Dr. Loggia’s work has been focused on the study of the role of neuroinflammation in human pain and other conditions

Education

PhD in Neurological Sciences, McGill University

Select Publications

1. Loggia ML, Kim J, Gollub RL, Vangel MG, Kirsch I, Kong J, Wasan AD, Napadow V. Default mode network connectivity encodes clinical pain: an arterial spin labeling study. Pain. 2013 Jan;154(1):24-33.

2. Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, Rosen BR, Napadow V, Hooker JM. Evidence for brain glial activation in chronic pain patients. Brain. 2015 Mar;138(Pt 3):604-15.

3. Albrecht DS, Forsberg A, Sandström A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML. Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation. Brain Behav Immun. 2019 Jan;75:72-83.

Highlights

2013: Early Career Award from the International Association for the Study of Pain (IASP)

2016: IASP Ulf Lindblom Young Investigator Award for Clinical Science

Section Editor for PAIN
Chief Specialty Editor for Frontiers in Pain Research
Editorial Board member for the Journal of Pain and Pain Medicine

Websites

Pain and Neuroinflammation Imaging Lab

Lawrence Wald

Professor

Magnetic Resonance Physics & Instrumentation Group (Director)

wald@nmr.mgh.harvard.edu
617-724-9706

Tagged:Brain, Brain Mapping, fMRI, Functional Magnetic Resonance Imaging, Hardware Development, High-field Imaging, Low-field Imaging, Magnetic Particle Imaging, Magnetic Resonance Imaging, MPI, MRI, RF Coil Development

Lawrence L. Wald, PhD, is currently a Professor of Radiology at Harvard Medical School and Affiliated Faculty of the Harvard-MIT Division Health Sciences Technology. He received a BA in Physics at Rice University, and a PhD in Physics from the University of California at Berkeley in 1992 under the direction of Prof. E.L. Hahn with a thesis related to optical detection of NMR. He obtained further (postdoctoral) training in Physics at Berkeley and then in Radiology and MRI at the University of California at San Francisco (UCSF). He began his academic career as an Instructor at the Harvard Medical School at McLean Hospital and since 1998 has been at the Massachusetts General Hospital Dept. of Radiology in the NMR Center (now the A.A. Martinos Center for Biomedical Imaging). His work has explored the benefits and challenges of highly parallel MRI and its application to highly accelerated image encoding and parallel excitation and ultra-high field MRI (7 Tesla) methodology for brain imaging including improved methods for matrix shimming and gradient coil design. His lab also focuses on motion mitigation methods, portable MRI technology, and is developing a prototype functional Magnetic Particle Imaging scanner.

Education

PhD in Physics, University of California at Berkeley

Publications

PubMed list of publications by LL Wald

Lawrence Wald Google Scholar Page

Highlights

1. Wiggins GC, Triantafyllou C, Potthast A, Reykowski A, Nittka M, Wald LL. 32-channel 3 Tesla receive-only phased-array head coil with soccer-ball element geometry. Magn Reson Med. 2006 Jul;56(1):216-23.

2. Setsompop K, Gagoski BA, Polimeni JR, Witzel T, Wedeen VJ, Wald LL. Blipped-controlled aliasing in parallel imaging for simultaneous multislice echo planar imaging with reduced g-factor penalty. Magn Reson Med. 2012 May;67(5):1210-24.

3. Cooley CZ, Stockmann JP, Armstrong BD, Sarracanie M, Lev MH, Rosen MS, Wald LL. Two-dimensional imaging in a lightweight portable MRI scanner without gradient coils. Magn Reson Med. 2015 Feb;73(2):872-83.

Website

Magnetic Resonance Physics & Instrumentation Group

Jacob Hooker

Professor

Chemical Neuroscience Program
Lurie Center for Autism

jhooker@mgh.harvard.edu
617-726-6596

Tagged:Aging, Alzheimer's Disease, Autism, Brain, Brain Mapping, Cardiovascular Disease / Disorders, Cardiovascular System, Chemistry, Clinical, fPET, Molecular Imaging, Multimodal Imaging, Pain, PET, PET-MRI, Positron Emission Tomography, Preclinical, Probe Development, Schizophrenia

Jacob Hooker, PhD, is currently Lurie Family Professor of Radiology in the Field of Autism Research and a Phyllis and Jerome Lyle Rappaport MGH Research Scholar. Dr. Hooker also serves as Scientific Director of the Lurie Center for Autism, as editor-in-chief for ACS Chemical Neuroscience and has associate or affiliate appointment throughout Boston/Cambridge including at Massachusetts Institute of Technology (MIT linQ Catalyst) and the Broad Institute (Stanley Center for Psychiatric Research).

Dr. Hooker grew up in Asheville, N.C., received his undergraduate degrees at NC State University and then completed his PhD in chemistry at UC Berkeley. In 2007, he was named Goldhaber Distinguished Fellow at Brookhaven National Laboratory. In 2009, he moved to Boston to begin his independent career at MGH and Harvard. That same year, he was awarded the Presidential Early Career Award for Scientists and Engineers by President Obama. The citation from the President noted his strong scientific record and his unique commitment to science mentorship. He has since been recognized by several additional national awards, including being named a Kavli Fellow by the National Academy of Sciences, received a NARSAD Independent Investigator Award and was an inaugural recipient of the Talented 12 Award by C&E News. Dr. Hooker’s research program focuses on advancing our understanding of the brain through the development and application of molecular imaging agents. His lab has provided insights into biochemical dysregulation of neurodegenerative diseases and neurodevelopmental and psychiatric disorders in the areas of neuroinflammation, epigenetics and neurochemical dynamics. The program has wide a scope including fundamental radiochemistry methodology, medicinal chemistry, radiotracer development, and preclinical and human magnetic resonance and positron emission tomography imaging.

Education

PhD in Chemistry, UC Berkeley

Select Publications

1. Zürcher NR, Loggia ML, Mullett JE, Tseng C, Bhanot A, Richey L, Hightower BG, Wu C, Parmar AJ, Butterfield RI, Dubois JM, Chonde DB, Izquierdo-Garcia D, Wey HY, Catana C, Hadjikhani N, McDougle CJ, Hooker JM. [11C]PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder. Mol Psychiatry. 2021 May;26(5):1659-1669. doi: 10.1038/s41380-020-0682-z. Epub 2020 Feb 19. PMID: 32076115; PMCID: PMC8159742.

2. Tseng CJ, McDougle CJ, Hooker JM, Zürcher NR. Epigenetics of Autism Spectrum Disorder: Histone Deacetylases. Biol Psychiatry. 2021 Dec 10:S0006-3223(21)01832-1. doi: 10.1016/j.biopsych.2021.11.021. Epub ahead of print. PMID: 35120709.

3. Zürcher NR, Walsh EC, Phillips RD, Cernasov PM, Tseng CJ, Dharanikota A, Smith E, Li Z, Kinard JL, Bizzell JC, Greene RK, Dillon D, Pizzagalli DA, Izquierdo-Garcia D, Truong K, Lalush D, Hooker JM, Dichter GS. A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism. Transl Psychiatry. 2021 Jan 11;11(1):33. doi: 10.1038/s41398-020-01170-0. PMID: 33431841; PMCID: PMC7801430.

4. Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM. In vivo human brain expression of histone deacetylases in bipolar disorder. Transl Psychiatry. 2020 Jul 8;10(1):224. doi: 10.1038/s41398-020-00911-5. PMID: 32641695; PMCID: PMC7343804.

5. Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Holt DJ, Greve DN, Pasternak O, Kubicki M, Wey HY, Hooker JM. Neuroepigenetic signatures of age and sex in the living human brain. Nat Commun. 2019 Jul 3;10(1):2945. doi: 10.1038/s41467-019-11031-0. PMID: 31270332; PMCID: PMC6610136.

6. Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into neuroepigenetics through human histone deacetylase PET imaging. Sci Transl Med. 2016 Aug 10;8(351):351ra106. doi: 10.1126/scitranslmed.aaf7551. PMID: 27510902; PMCID: PMC5784409.

Websites

Chemical Neuroscience Program

Lurie Center for Autism

Ciprian Catana

Professor

Integrated MR-PET Imaging Laboratory (Director)

ccatana@mgh.harvard.edu
617-643-4885

Dr. Catana is director of Integrated MR-PET Imaging at the MGH Martinos Center for Biomedical Imaging and a Professor in Radiology at Harvard Medical School. He has extensive experience in combining PET and MRI and is currently focusing on developing quantitative MR-PET for human use. Working closely with dozens of basic science researchers and physician-scientists, Dr. Catana is applying this novel technology to the study of the normal brain and neuropsychiatric diseases, as well as exploring its clinical potential for cardiovascular and pulmonary diseases and whole-body oncological applications.

Education

PhD in Biomedical Engineering, University of California, Davis
MD in Medicine, University of Medicine & Pharmacy of Targu-Mures, Romania

Select Publications

1. Catana C, Procissi D, Wu Y, Judenhofer MS, Qi J, Pichler BJ, et al. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci U S A. 2008;105(10):3705-10.

2. Catana C, van der Kouwe A, Benner T, Michel CJ, Hamm M, Fenchel M, et al. Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med. 2010;51(9):1431-8.

3. Catana C, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Cherry SR. Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner. J Nucl Med. 2006;47(12):1968-76.

Highlights

Course Director, MIT HST563

Website

Integrated MR-PET Imaging Laboratory

Vitaly Napadow

Professor

Napadow Lab (Director)
Center for Integrative Pain NeuroImaging (Director)

vitaly@mgh.harvard.edu

Tagged:Acupuncture, Brain, Clinical, EEG, fMRI, High-field Imaging, Meditation, MRI, Multimodal Imaging, Pain

Vitaly Napadow is a Professor at Harvard Medical School and the Director of the Scott Schoen and Nancy Adams Discovery Center for Recovery from Chronic Pain at Spaulding Rehabilitation Hospital and the Director of the Center for Integrative Pain NeuroImaging (CiPNI)) at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital. Somatosensory, cognitive, and affective factors all influence the malleable experience of chronic pain, and Dr. Napadow’s Lab has applied human functional and structural neuroimaging to localize and suggest mechanisms by which different brain circuitries modulate pain perception. Dr. Napadow’s neuroimaging research also aims to better understand how non-pharmacological therapies, from acupuncture and transcutaneous neuromodulation to cognitive behavioral therapy and mindfulness meditation training, ameliorate aversive perceptual states such as pain. Dr. Napadow has more than 200 publications in leading peer-reviewed scientific journals, is past-President of the Society for Acupuncture Research, and serves on the board of the US Association for the Study of Pain (USASP) and numerous conference, journal, and NIH review panels. He was recently named to the Distinguished Investigator Council by the Academy for Radiology & Biomedical Imaging Research and received the Excellence in Integrative Medicine Research Award by the European Society for Integrative Medicine.

Education

PhD, MIT/HMS HST Medical Engineering and Medical Physics (MEMP) Program

Select Publications

1. Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum. 2010 Aug;62(8):2545-55.

2. Lee J, Mawla I, Kim J, Loggia ML, Ortiz A, Jung C, Chan ST, Gerber J, Schmithorst VJ, Edwards RR, Wasan AD, Berna C, Kong J, Kaptchuk TJ, Gollub RL, Rosen BR, Napadow V. Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics. Pain. 2019 Mar;160(3):550-560.

3. Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V. Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture. Brain. 2017 Apr 1;140(4):914-927.

Highlights

Inventor on awarded and licensed patent: “Systems and methods for Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS)”

Co-President of the Society for Acupuncture Research for 8 years

PI of several NIH R01 grants and P01 program project grant titled “Boosting mind-body mechanisms and outcomes for chronic pain”

Websites

Napadow Lab
Center for Integrative Pain NeuroImaging (CIPNI)