Jacob Hooker, PhD, is currently the Phyllis and Jerome Lyle Rappaport MGH Research Scholar and an Associate Neuroscientist at Massachusetts General Hospital. He is a Professor of Radiology at Harvard Medical School and Director of Radiochemistry at the Martinos Center for Biomedical Imaging. He also serves as an associate editor for ACS Chemical Neuroscience.

Dr. Hooker grew up in Asheville, N.C., received his undergraduate degrees at NC State University and then completed his PhD in chemistry at UC Berkeley. In 2007, he was named Goldhaber Distinguished Fellow at Brookhaven National Laboratory. In 2009, he moved to Boston to begin his independent career at MGH and Harvard. That same year, he was awarded the Presidential Early Career Award for Scientists and Engineers by President Obama. The citation from the President noted his strong scientific record and his unique commitment to science mentorship. He has since been recognized by several additional national awards, including being named a Kavli Fellow by the National Academy of Sciences, received a NARSAD Independent Investigator Award and was an inaugural recipient of the Talented 12 Award by C&E News.

Dr. Hooker’s lab has the mission of accelerating the study of the living human brain and nervous system through development and application of molecular imaging agents. The lab has developed and patented several imaging technologies for neuroscience, including a first-in-class radiotracer for neuroepigenetic imaging.

Education

PhD in Chemistry, UC Berkeley

Select Publications

1. Gilbert TM, Zurcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, et al. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019;129(1):364-72.

2. Strebl MG, Campbell AJ, Zhao WN, Schroeder FA, Riley MM, Chindavong PS, et al. HDAC6 Brain Mapping with [(18)F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination. ACS Cent Sci. 2017;3(9):1006-14.

3. Zhao W, Lee HG, Buchwald SL, Hooker JM. Direct (11)CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions. J Am Chem Soc. 2017;139(21):7152-5.

Website

Chemical Neuroscience Program