Dr. Michele Scipioni is dedicated to advancing our understanding of biological and neurochemical processes through the development of integrated PET/MRI technologies. With several years of experience, Dr. Scipioni offers a multidisciplinary perspective, drawing from mechanical engineering, computer science, medical imaging, and medical physics.
During his doctoral studies, Dr. Scipioni’s research focused on developing software tools and algorithms for PET image reconstruction and kinetic modeling. This work included a particular interest in leveraging quantitative PET for diagnosing cardiac amyloidosis, and combining DCE-MRI and PET imaging for liver cancer diagnosis.
At the “Athinoula A. Martinos” Center for Biomedical Imaging, Dr. Scipioni’s work has primarily revolved around the design and manufacturing of a next-generation, 7T MR-compatible, brain-dedicated PET scanner: NeuroSphere PET. In this context, he contributed to the innovative mechanical design required to achieve its unconventional spherical geometry, developed PET detector characterization setups, and implemented cooling and RF shielding solutions to optimize system performance and integration with the pre-existing MRI host system. This advanced system is anticipated to open new avenues for in-depth neuroscience research, offering unprecedented insights into brain function and disease.
Education
Ph.D. in Biomedical Engineering (Medical Imaging), M.Sc. in Biomedical Engineering, B.Sc. in Biomedical Engineering
Select Publications
Scipioni M, Corbeil J, Allen MS, Byars L, Schmidt FP, Galve P, Mareyam A, Kapusta M, Valcayo FA, Zhang X-M, Herraiz JL, Ambartsoumian G, Kirsch J, Udías JM, Rosen B, Wald LL, Judenhofer M, Catana C. “Design and Development of the Human Dynamic NeuroChemical Connectome Scanner,” 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD), Vancouver, BC, Canada, 2023 11 04-11, pp. 1-2, doi: 10.1109/NSSMICRTSD49126.
2023.10337891
Scipioni M, Pedemonte S, Santarelli MF, Landini L. “Probabilistic Graphical Models for Dynamic PET: A Novel Approach to Direct Parametric Map Estimation and Image Reconstruction”. IEEE Trans Med Imaging. 2020 01; 39(1):152-160. PMID: 31199257
Fuin N, Catalano OA, Scipioni M, Canjels LPW, Izquierdo-Garcia D, Pedemonte S, Catana C. “Concurrent Respiratory Motion Correction of Abdominal PET and Dynamic Contrast-Enhanced-MRI Using a Compressed Sensing Approach”. J Nucl Med. 2018 09; 59(9):1474-1479. PMID: 29371404
Genovesi D, Vergaro G, Giorgetti A, Marzullo P, Scipioni M, Santarelli MF, Pucci A, Buda G, Volpi E, Emdin M. “[18F]-Florbetaben PET/CT for Differential Diagnosis Among Cardiac Immunoglobulin Light Chain, Transthyretin Amyloidosis, and Mimicking Conditions”. JACC Cardiovasc Imaging. 2021 01; 14(1):246-255. PMID: 32771577
Highlights
2019: Best Doctoral Thesis Award [GNB – National Bioengineering Group]
Associated Labs
Integrated MR-PET Imaging Laboratory